18/01/2022. Naproxen - mechanism antiviral action

Regarding the mechanism of the antiviral effect exerted by naproxen: In a laboratory study by French scientists, it was shown that naproxen binds to the N protein of the SARS-CoV-2 virus causing -inhibition of replication, i.e. multiplication of the virus -antiviral effect -reduction of inflammation by inhibition of cyclooxygenase cascade and cytokine storm -protective effect on the bronchial epithelium - maintaining its continuity and consequently reducing inflammation. The N protein of the virus is a nucleoprotein, a nucleocapsid protein. Blocking this protein by Naproxen causes a significant reduction in its function in the process of multiplication of the virus, development, and spread of inflammation. Protein N role: -binding to the viral RNA strand and the onset of replication, viral multiplication. -activation of the cyclooxygenase/cytokine storm cascade -impairment of host-cell defense mechanisms and acceleration of cell death.